General Hospital: Night Shift is an American prime time serial that first aired on Soapnet for a 13-episode run from July 12, 2007 to October 4, 2007. A spin-off of the ABC Daytime soap opera General Hospital, the show is SOAPnet's first original scripted drama series and follows the nighttime adventures of familiar and new characters around the hospital. As of March 2008, the first season of the series was "SOAPnet's most watched series ever," with ABC Daytime and SOAPnet President Brian Frons noting that Night Shift drew more than 1 million new viewers to the channel during its first season. With its reruns gaining higher ratings than those of General Hospital on SOAPnet, a second season was expected, though Frons noted that the same crew producing two shows had taken its toll.It was announced in May 2008 that Lisa de Cazotte would serve as Executive producer for season two, joined by Head writer Sri Rao. The 14 new episodes of Night Shift began taping in high-definition in June 2008, with the series airing Tuesdays at 11 p.m. and premiering on July 22, 2008. SOAPnet said the second season "will feature new and returning characters as well as the return of 'legacy' characters from GH. In addition, the continuity between story lines on Night Shift and GH will match." The second season finished its run on October 21, 2008.

Families, friends, enemies and lovers experience life-changing events in the large upstate New York city of Port Charles, which has a busy hospital, upscale hotel, cozy diner and dangerous waterfront frequented by the criminal underworld.

A young woman working her first night shift at a remote motel begins to suspect that she is being followed by a dangerous character from her past. As the night progresses and increasingly supernatural events occur, she quickly finds out that nothing is what it appears to be.

A devoted switchboard operator is the village guardian angel.

A mad doctor puts together a new body by using body parts he steals from a mortuary at the hospital where he works.

Jung Ha Yoon is a graduate student who successfully passed the bar exam. However, she is not finished as she wants to be a medical malpractice litigation specialist. She works at a hospital to look to gain experience and there she meets other doctors who work there.

The stories of the men and women who work the overnight shift at San Antonio Memorial Hospital. They are an irreverent and special breed, particularly adrenaline junkie T.C. Callahan.

Heo Joon (Yoon Tae Young) is a doctor. His wife was killed by an unidentified man right in front of him. Since the murder, he quit his job at a university hospital and searches out for his wife’s killer. He opens a secret late night clinic to capture the killer. Hong Na Kyung (Ryu Hyun Kyung) is a surgeon at Heo Joon’s clinic.

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